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projects: chromatin enzymes
projects: chromaint factors

projects: DNA ladders
projects: polycistronic expression
picture & movie gallery
gallery: amino acids
gallery: secondary structure
gallery: selected proteins
gallery: protein/DNA complexes

background reading


Made on a Mac

RCC1/nucleosome crystals RCC1/nucleosome crystal packing

Postdoctoral positions are available in the Tan Laboratory at Penn State to determine the structures of epigenetic chromatin enzymes in complex with the nucleosome using crystallography and cryoelectron microscopy. Preliminary crystals are available for several projects.

Our efforts are enhanced by:

  • techniques to reconstitute multicomponent complexes in vitro and in vivo
    (Prot. Expr. Purif., 40:385, 2005, Methods, 41:271, 2007),

  • crystallization strategies developed for the RCC1-nucleosome complex (Nature, 467:562, 2010, Anal. Biochem, 442:138, 2013) and the Polycomb PRC1-nucleosome complex (Nature, 514,591, 2014),

  • access to Penn State's Titan Krios electron microscope purchased in 2017 (Falcon3 3EC and Gatan K2 detectors, Volta phase plate).

The Center for Gene Regulation at Penn State University is a dynamic and highly collaborative environment which includes the groups of Drs. Lu Bai, David Gilmour, Shaun Mahony, Frank Pugh, Joe Reese, Yanming Wang and Song Tan, each with research programs targeted at understanding the molecular basis for gene regulation on chromatin templates. The Center moved to renovated research space in November 2009.

Crystallographers, electron microscopists, molecular biologists and biochemists are encouraged to apply. Prior experience with macromolecular crystallography, cryoelectron microscopy and/or protein expression and purification is preferred. Please send curriculum vitae and the names and contact information of three references to Song Tan, email: .

Penn State is committed to affirmative action, equal opportunity and the diversity of its workforce

video introduction | projects: | chromatin enzymes | chromatin factors | DNA ladders | polycistronic expression | picture & movie gallery: | amino acids | secondary structure | selected proteins | protein/DNA complexes |
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This page is maintained by Song Tan: (814-865-3355)
Department of Biochemistry & Molecular Biology, 108 Althouse Lab, University Park, PA 16802

This page was last updated on October 12, 2020.

Penn State BMB Eberly College of Science