Postdoctoral positions are available in the Tan Laboratory at Penn State to determine the structures
of epigenetic chromatin enzymes in complex with the nucleosome using crystallography and cryoelectron microscopy. Preliminary crystals are available for several projects.
Our efforts are enhanced by:
to reconstitute multicomponent complexes in vitro and in vivo
(Prot. Expr. Purif.,
40:385, 2005, Methods, 41:271, 2007),
- crystallization strategies developed for the RCC1-nucleosome complex (Nature, 467:562, 2010, Anal. Biochem, 442:138, 2013) and the Polycomb PRC1-nucleosome complex (Nature, 514,591, 2014),
- access to Penn State's Titan Krios electron microscope purchased in 2017 (Falcon3 3EC and Gatan K2 detectors, Volta phase plate).
The Center for Gene Regulation at Penn State University is a dynamic
and highly collaborative environment which includes the groups of
Drs. Lu Bai, David Gilmour, Shaun Mahony, Frank
Reese, Yanming Wang and Song
Tan, each with research programs targeted at understanding the
molecular basis for gene regulation on chromatin templates. The Center moved to renovated research space in November 2009.
Crystallographers, electron microscopists, molecular biologists and biochemists are encouraged to apply. Prior experience
with macromolecular crystallography, cryoelectron microscopy
and/or protein expression and purification is preferred. Please send curriculum vitae and
the names and contact information of three references to Song Tan, email: firstname.lastname@example.org .