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Welcome to my homepage at PSU.

I am a computational and evolutionary biologist. I desire to know the genetic bases of a variety of organismal features (phenotypes): why and how organisms differ from each other, why people could get sick, how developmental process are controlled, etc.

To approach the above goal, I study two related aspects of biology: (1) how the biological systems (development, gene regulation, mutational effects, etc.) work in an organism, and (2) what the genetic differences between organisms are. I have studied the roles of nonsense-mediated mRNA decay in genome-wide gene expression regulation, the evolution of alternative splicing, the evolution of sex-determination system in Drosophila, mammalian comparative genomics, and human diseases (including virus infections). I am now focusing on gene expression regulation by different mechanisms and its contribution to organismal feature diversity.


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Nei Lab | Institute of Molecular Evolutionary Genetics | Department of Biology

The Pennsylvania State University

This website is maintained by Zhenguo Zhang

Last update: 01/23/2014

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