Laboratory of Ross Hardison

Current Directory Entry

Ross Hardison is a professor of biochemistry at the Penn State University. Ross and his co-workers (who are part of the Center for Comparative Genomics and Bioinformatics) use comparative genomics to predict gene regulatory modules, test them for function in the laboratory, and work to pull all this together into a more thorough understanding of global regulation of erythroid genes. The techniques developed and utilized in this and associated labs should be applicable to a wide variety of regulated systems and organismal groups.

• Description of Research
• Publications, including full text for many recent articles
• Useful datasets, including predicted erythroid cis-regulatory modules in the mouse genome
• Textbook, full text and free Working with Molecular Genetics

Connections and collaborations at PSU

• Almost all our work is done in a long-standing collaboration with Dr. Webb Miller.
• Center for Comparative Genomics and Bioinformatics (CCGB). This site has:
  • Algorithms and servers for genome sequence alignments
  • Methods to analyze of those alignments for functional prediction and greater understanding of genome evolution
  • Databases, servers and metaservers to facilitate that analysis.
• Globin Gene Server
• Department of Biochemistry and Molecular Biology
• The Huck Institutes of the Life Sciences
• The Pennsylvania State University.

Collaborations with researchers at other institutions

• Whole-genome alignments and analysis with Dr. David Haussler in the Center for Biomolecular Science and Engineering at the University of California at Santa Cruz and Howard Hughes Medical Institute
• Sequence alignments, analysis and database development with Dr. Jim Kent at UCSC.
• Application of genomics and bioinformatics to understand erythroid gene regulation with Dr. Mitch Weiss, and co-workers at The Children's Hospital of Philadelphia.
• Assist Dr. Ivan Ovcharenko at the Lawrence Livermore National Laboratory in his development of a suite of tools at dcode.org for genome sequence alignments, discovery of candidate cis-regulatory elements and conserved matches to transcription factor binding sites.

Page created: Wednesday, 12-Jan-2005, last modified 15-Jan-2005

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