Pamela H. Correll

Education

Research Areas -  Macrophage Biology and Innate Immunity & Cell Signaling and Transformation

We and others have identified a role for STK receptor tyrosine kinase in regulating macrophage-mediated inflammatory responses as well as identified a naturally-occurring truncated form of STK (Sf-STK) as a susceptibility gene for Friend virus-induced erythroleukemia.  The current focus of our research is to understand the signals induced by STK that mediate these diverse biological responses.

Teaching Areas 

Honors and Awards

Publications

Correll PH, Morrison AC, Lutz MA.  2003.  Receptor Tyrosine Kinases and the Regulation of Macrophage Activation.  J Leukoc Biol.  (in press).

Teal HE, Craici A, Paulson RF, Correll PH.  2003.  Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.  J Hemat Stem Cell Res.  23(2): 165-177.

Lutz MA, Correll PH.  2003.  Activation of CR3-mediated phagocytosis by MSP requires the RON receptor, tyrosine kinase activity, phosphatidylinositol 3-kinase, and protein kinase C zeta.  J Leukoc Biol.  73(6): 802-14.

Forgie A, Wyatt S, Correll PH, Davies AM.  2003.  Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.  Development.  130(5): 995-1002.

Finkelstein L, Ney P, Liu QP, Paulson RF, Correll PH.  2002.  Sf-Stk kinase activity and the Grb2 binding site are required for Epo-independent growth of primary erythroblasts infected with Friend virus.  Oncogene.  21(22): 3562-3570.

Yu Y, Correll PH, Vanden Heuvel JP.  2002.  Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for PPAR gamma-dependent mechanism.  Biochim Biophys Acta.  1581(3): 89-99.

Morrison AC, Correll PH.  2002.  Activation of the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase by macrophage-stimulating protein results in the induction of arginase activity in murine peritoneal macrophages.  J Immunol.  168(2): 853-60.

Lutz MA, Gervais F, Bernstein A, Hattel AL, Correll PH.  2002.  STK receptor tyrosine kinase regulates susceptibility to infection with Listeria monocytogenes.  Infect Immun.  70(1): 416-418.

Hidaka M, Caruana G, Stanford WL, Sam M, Correll PH, Bernstein A.  2000.  Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells.  Mech Dev.  90(1):3-15.

Liu QP, Fruit K, Ward J, Correll PH.  1999.  Negative regulation of macrophage activation in response to IFN-gamma and LPS by the STK/RON receptor tyrosine kinase.  J Immunol.  163(12):6606-6613.

Persons DA, Paulson RF, Loyd MR, Herley MT, Bodner SM, Bernsten A, Correll PH, Ney PA.  1999.  Fv2 encodes a truncated form of the STK receptor tyrosine kinase.  Nat Gen.  23(2):159-65.

Correll PH, Iwama A, Tondat S, Mayrhofer G, Suda T, Bernstein A.  1997.  Deregulated inflammatory response in mice lacking the STK/RON receptor tyrosine kinase.  Genes & Function.  1:69-83.

Bernstein A, Correll PH, Paulson RF, Potter M.  1996.  In vitro and in vivo approaches to the molecular analysis of mouse hematopoiesis.  In Mammalian Development, P Lonai (ed.) Harwood Academic Publishers, pp 101-134.

Correll PH, Colilla S, Karlsson S.  1994.  Retroviral vector design for long-term expression in murine hematopoietic cells in vivo.  Blood.  84(6):1812-1822.

Correll PH, Colilla S, Dave HPG, Karlsson S.  1992.  High levels of human glucocerebrosidase activity in macrophages of long-term reconstituted mice following retroviral infection of hematopoietic stem cells.  Blood.  80:331-336.

Correll PH, Kew Y, Perry LK, Brady RO, Karlsson S.  1990.  Expression of human glucocerebrosidase in long-term reconstituted mice following retroviral-mediated gene transfer into hematopoietic stem cells.  Hum Gene Ther.  1(3):277-87.

Correll PH, Fink JK, Brady RO, Perry LK, Karlsson S.  1989.  Production of human glucocerebrosidase in mice after retroviral gene transfer into multipotential hematopoietic progenitor cells.  Proc Natl Acad Sci U S A.  86(22):8912-6.