What we do:

Our mission is to understand how proteins are selectively produced at the right time and in the right place to execute complex biological processes such as cell cycle progression and cellular differentiation. In particular, we are studying how protein translation and degradation are regulated by the tmRNA protein-tagging system, and how proteins are localized within the bacterial cell. We are also exploiting what we have learned about these fundamental processes to develop reagents that control bacterial development and proliferation, to be used for novel antibiotics and for basic scientific research.


Recent Publications    (all publications are listed here)

  1. BulletHayes CS and Keiler KC (2010) “Beyond ribosome rescue: tmRNA and co-translational processes.” FEBS Lett 584: 413-419. link

  2. BulletRussell JH and Keiler KC (2009) “Subcellular localization of a bacterial regulatory RNA.” PNAS 106: 16405-16409. link

  3. BulletCheng L and Keiler KC (2009) “Correct timing of dnaA transcription and initiation of DNA replication requires trans-translation.” J Bacteriol 191: 4268-4275. link

  4. BulletKeiler KC (2008) “Biology of trans-translation.” Annu Rev Microbiol 62: 133-151. link

  5. BulletRussell JH and Keiler KC (2008) “Screen for localized proteins in Caulobacter crescentus.” PLoS ONE 3: e1756. link

  6. BulletRussell JH and Keiler KC (2007) “Peptide signals encode protein localization.” J Bacteriol 189: 7581-5. pdf

  7. BulletHong S-J et al. (2007) “Proteomic identification of tmRNA substrates.” PNAS 104: 17128-33. pdf

  8. BulletCheng L et al. (2007) “Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease.” Protein Sci 16:1535-42. pdf

  9. BulletKeiler KC (2007) “Physiology of tmRNA: what gets tagged and why?” Curr Opin Microbiol 10:169-75. pdf

  10. BulletLessner FH et al. (2007) “Proteolytic adaptor for tmRNA-tagged proteins from α-proteobacteria.” J Bacteriol 189:272-5. pdf

  11. BulletHong S-J et al. (2005) “Cell-cycle regulated degradation of tmRNA is controlled by RNase R and SmpB.” Mol Microbiol 57:565-75. pdf


NIH - NIGMS R01 68720 “Role of tmRNA in Development of Caulobacter crescentus.”

DTRA - W911NF0610144 “Selection of tmRNA inhibitors as antibacterial and plasmid elimination agents.”

401 Althouse Lab • University Park, PA 16802 • (814) 863-0801

Ken’s BMB Faculty pagehttp://www.bmb.psu.edu/faculty/keiler/keiler.htmlhttp://www.bmb.psu.edu/faculty/keiler/KeilerLab/MainPage.htmshapeimage_2_link_0