Dr. Guo's research areas are in solid state electronic materials and devices. She has been carrying out research in ferroelectric single crystals and ceramics, electro-optic and photorefractive materials, high T_C superconductor substrates, crystal chemistry in conjunction with thin film technology, and microwave (and frequency-agile microwave) dielectrics. Her research projects have been funded through NSF, ONR, DARPA and industrial sponsors. She is the Director of a NSF sponsored REU-Site Program (NSF EE REU) hosted by the Department of Electrical Engineering. She is also a faculty member involved in the NSF Center for Dielectric Studies (CDS, MRI, PSU), the International Center for Actuators and Transducers (ICAT, MRI, PSU), the Ferroelectric Resource Center for Frequency Agile Materials for Electronics (FAME), the Electrooptics Center (EO Center, EE, PSU), and the Pennsylvania Center for Optical Technologies (COT, Lehigh U. and PSU).

Dr. Guo received her B.S. (honors) and M.S. in Electrical Engineering from Xian Jiaotong University, Xian, China, in 1982 and 1984 respectively. She was a faculty member in the Department of Electrical Engineering, Xian Jiaotong University, from 1984 to 1985. She received her Ph.D. in Solid State Science from Penn State University in 1990. She was a research faculty member of the Materials Research Laboratory (MRL) and a graduate faculty member of the Intercollege Graduate Program in Materials (IGPM), from 1991 to 1999. She joined the faculty of the Electrical Engineering Department, Penn State University, in 1999.

Dr. Guo is a Fellow of ACerS, a senior member of IEEE, a member of AAAS , MRS, SPIE, LEOS, and UFFC. She held the elected office as the Chair of the Electronics Division, American Ceramic Society, in 2002-2003. She is a member of the UFFC-IEEE Ferroelectrics Committee. She has organized and co-organized several symposia and meetings nationally and internationally in the areas of ferroelectrics, dielectrics, electronics, and optical & photorefractive materials and devices. She has co-edited several books (ACerS Transaction Series and SPIE proceedings), and has authored or co-authored more than 140 scientific papers & review articles. She serves currently on the editorial board of journal of Phase Transitions, Journal of Korean Ceramic Society, and Ferroelectrics Letters.