MOLECULAR AND CELL BIOLOGY 251H

 

Fall Semester 2003

 

Time; Location:                    MWF 12. 20 -1:10, 112 Thomas

 

Instructor:                             Dr. Ola Sodeinde

                                                429 South Frear

                                                865-0004

                                                oas1@psu.edu

 

Office Hours:                       Friday, 2.00 - 4 pm and/or by appointment.

 

Text:                                       Molecular Biology of the Cell, Fourth Edition

Authors:                                Alberts et. al.

 

 

READING ASSIGNMNETS

You are expected to read the appropriate pages from the textbook in preparation for class.  Participation in class discussion is strongly encouraged.  All students are to required to read the articles for all student presentations (scheduled for the latter part of the course.)  To fuel class discussions, write down whatever questions or thoughts that you may have from your reading of the material.

 

PRESENTATIONS

There will be a total of eight presentations.  Each of you will be assigned to a group of about three students.  Each person should plan on holding the floor for about 15 minutes.  A two page double spaced summary of your contribution must be handed to me on the day of your presentation.

 

Each group presentation will focus on two papers.  One paper is a review article and its reference will be provided.  The entire class is required to read the review article.  The other is to be a research article and is to be chosen (with my pre-approval at least a week in advance) based upon your reading of the review paper.  The objective of the research paper is to give you an appreciation of how scientific data is obtained, presented and interpreted. You will find this to be a challenging (and hopefully, a highly rewarding) exercise!  All three students are expected to contribute equally to the presentation and should meet with me as a group at least once before the presentation to discuss any problems.

 

The format of your presentations should involve the use of xeroxed overheads of relevant figures/data from the research article.  The BMB office in 108 Althouse can make photocopies and provide you with tranparencies.  Alternatively, you may give a Powerpoint presentation.

 

 


GRADING and EXAMS

There will be three midterm exams (a combination of multiple-choice and short essays), each covering the material presented during the respective sections of the course.  The final exam will be of short-essay format testing material covered during the student presentations. 

 

Exam 1:                                  20%

Exam 2:                                  20%

Exam 3:                                  20%

Exam 4:                                  20%

Class presentation:              10%

Written summary:               10%

 

Please, make every effort to take exams as scheduled.

 

Exams will emphasize but will not necessarily be confined to the material presented in class.

 

POTENTIAL REVIEW PAPERS FOR CLASS PRESENTATION

Links to some of these Scientific American articles can be found at: http://www.sciam.com/

 

1.     Magic Bullets fly again.  Oct 2001

 

2.     Budding vesicles in cells by J. E. Rothman and L. Orci.  Mar 1996.  Vol. 274: 70-75

 

3.     Telomeres, Telomerase and Cancer by C. W. Greider, and E. H. Blackburn. Feb 1996.

 

4.     In Search of AIDS-Resistance Genes by Stephen J. O'Brien and Michael Dean.  Sept 1997

 

5.     Cloning For Medicine by Ian Wilmut. Dec 1998.

 

6.     Building a Brainier Mouse by Joe Z. Tsien.  April 2000. 

 

7.     Attacking Anthrax. March 2002

 

8.     Microarrays.  Feb 2002

 

9.     Proteomics  April 2002

 

 


 

 

DATE

TOPIC

TEXT CHAPTER

1

9/2, T

The Cell

1

2

9/3, W

Principles of Biosynthesis

2 (58-62; 68-108*)

3

9/5, F

Protein Structure

2 (62-63), 3 (129-156)

4

9/8, M

Protein Function

3 (156-187)

5

9/10, W

Structure and Function of DNA

4  (191-7)

6

9/12, F

Chromosomes

4 (198-212)

7

9/15, M

DNA Replication

5 (238-255)

8

9/17, W

DNA Replication and Repair

5 (255-75)

9

9/19, F

DNA Recombination

5 (275-85)

10

9/22, M

Transcription

6  (299-315)

11

9/24, W

RNA Processing

6  (315-335)

12

9/26, F

Translation

6 (335-365)

 

9/29, M

EXAM 1

 

13

10/1, W

DNA Binding Proteins

7(379-95)

14

10/3, F

Transcriptional Control

7 (395-415)

15

10/6, M

Posttranscriptional Control

7 (427-52)

16

10/8, W

Methods: Biochemistry and Cell Biology

8 (469-491)

 

10/10, F

Study Day (No Class)

 

17

10/13, M

Methods: Molecular Genetics

8 (491-513)

18

10/15, W

Methods: Protein Structure/Function

8 (513-545)

19

10/17, F

Methods: Genetic and Genomics

8 (513-545)

20

10/20, M

Microscopy

9 (547-579)

21

10/22, W

Membrane Structure

10(583-599)

22

10/24, F

Membrane Transport

11 (615-631)

23

10/27, M

Ion Channels and Nerve Function

11 (631-656)

 

10/29, W

EXAM 2

 

24

10/31, F

Intracellular Compartments and Protein Sorting

12 (659-669)

25

11/3, M

Nuclear, Mitochondrial, Chloroplast Protein Transport

12 (669-689)

26

11/5, W

The Endoplasmic Reticulum

12 (689-709)

27

11/7, F

Vesicular Traffic

13 (711-726)

28

11/10, M

Transport from the ER to the Golgi and Lysosomes

13 (726-746)

29

11/12, W

Endocytosis and Exocytosis

13 (746-765)

30

11/14, F

Mitochondrial Function

13 (767-793); 2 (68-108*)

31

11/17, M

Chloroplasts and Photosynthesis

13 (793-807)

32

11/19, W

Organelle Genomes

13 (808-821)

33

11/21, F

Class Discussion

 

 

11/24, M

EXAM 3

 

 

11/26, W

THANKSGIVING

 

 

11/28, F

THANKSGIVING

 

34

12/1, M

Student Presentation

 

35

12/3, W

Student Presentation

 

36

12/5, F

Student Presentation

 

37

12/8, M

Student Presentation

 

38

12/10, W

Student Presentation

 

39

12/12, F

Student Presentation

 

 

12/18, R

FINAL EXAM  (12.20 2.10)