Department of Biology  
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Selected Publications

Zhang, Yang, S-L., Yang, M., Herrlinger, S., Shao, Q., Collar, JL., Fierro, E., Shi, Y., Liu, A., Lu, H., Herring, BE., Zhao, Z., and Chen, J-F. (2019) Modeling microcephaly with cerebral organoids and mice reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly for neural progenitor cell maintenance. Nature Communications. Accepted.

Liu, J. and Liu, A. (2019) Immunohistochemistry and RNA in situ hybridization in mouse brain development. Methods in Molecular Biology, second edition. Edited by Simon Sprecher. In press

Liu, A. (2019) Proteostasis in the Hedgehog signaling pathway. Seminars in Cell and Developmental Biology, in press.

Wang, Y., Zeng, H. and Liu, A. (2019) Distinct Activities of Gli1 and Gli2 in the Absence of Ift88 and the Primary Cilia. J. Dev. Biol., 7(1): e5.

Wang, S., Liu, A., Wu, G., Ding, H-F., Huang, S., Nahman, S. and Dong, Z. (2018) CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation. Nature Communications, 9(1):1234. doi: 10.1038/s41467-018-03628-8.

Agbu, SO., Liang, Y., Liu, A. and Anderson, KV. (2018) The Small GTPaseRSG1 Controls a Final Step in Primary Cilia Initiation. Journal of Cell Biology, 217(1):413-427. doi: 10.1083/jcb.201604048.

Cai, H. and Liu, A. (2017) Spop specifically regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse neural tube. Developmental Biology, 432 (1):72-85, DOI: 10.1016/j.ydbio.2017.04.002.

Yang, N., Leung, E., Liu, C., Li L., Eguether, T., Yao, XJ., Jones, EC., Norris, DA., Liu, A., Clark, RA., Roop, DR., Pazour, GJ., and Chen J. (2017) INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma (BCC). Oncogene, 36: 4997-5005. PMID: 28459465. DOI: 10.1038/onc.2017.117.

Cai H and Liu A. (2016) Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Proc Natl Acad Sci U S A.,113 (51): 14751-14756, PMID: 27930311 DOI:10.1073/pnas.1612520114

Chang R, Petersen J R, Niswander L, Liu A. (2015) A hypomorphic allele reveals an important role of Inturned in mouse skeletal development. Developmental Dynamics, 244(6): 736-747. DOI 10.1002/dvdy.24272

Liu, J., Zeng, H. and Liu, A. (2015) The loss of HH responsiveness by a non-ciliary Gli2 variant. Development, 142: 1651-1660. doi:10.1242/dev.119669 (Highlighted article, recommended by Faculty of 1000)

Ye, X., Zeng, H., Ning, G., Reiter J. and Liu, A. (2014) C2cd3 regulates centriolar maturation and IFT protein recruitment essential for cilia formation. Proc Natl Acad Sci U S A., 111(6): 2164-2169. DOI:10.1073/pnas.1318737111

Liu, A. and Eggenschwiler, J. (2014) Identifying essential genes in mouse development via an ENU-based forward genetic approach. Methods in Molecular Biology: Mouse Molecular Embryology (chapter 7), 1092: 95-118. Edited by Mark Lewandowski. Springer, New York, NY. ISBN: 978-1-60327-290-2. DOI: 10.1007/978-1-60327-292-6_7.

Liu, J. and Liu, A. (2014) Immunohistochemistry and RNA in situ hybridization in mouse brain development. Methods in Molecular Biology, 1082: 269-283. Edited by Simon Sprecher. DOI: 10.1007/978-1-62703-655-9_18

Wang, C., Low, W-C, Liu, A., and Wang, B (2013) Centrosomal Protein Dzip1 Regulates Hedgehog Signaling by Promoting Cytoplasmic Retention of Transcription Factor Gli3 and Affecting Ciliogenesis J. Biol. Chem., 288: 29518-29. doi: 10.1074/jbc.M113.492066

Dai, D., Li, L., Huebner, A., Zeng, H., Guevara, E., Claypool, D., Liu, A., Chen, J. (2013) Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death and Differentiation, 20: 130-8. doi: 10.1038/cdd.2012.104

Liu A (2012) The Cilium-Dependent Hedgehog Signaling in Mammals. Cell Dev Biol ,1:e116. doi:10.4172/2168-9296.1000e116

Liu, J., Heydeck, W., Zeng, H. and Liu, A. (2012) Dual Function of Suppressor of Fused in Shh Pathway Activation and Mouse Spinal Cord Patterning. Developmental Biology, 362: 141-153. DOI: 10.1016/j.ydbio.2011.11.022

Ye, X and Liu, A. (2011) Hedgehog signaling: mechanism and evolution. Frontiers in Biology, 6(6): 504-521. DOI: 10.1007/s11515-011-1146-2

Heydeck, W. and Liu, A. (2011) PCP effector proteins Inturned and Fuzzy play non-redundant roles in the patterning but not convergent extension of mammalian neural tube. Developmental Dynamics, 240 (8): 1938-1948. doi: 10.1002/dvdy.22696

Pyrgaki, C., Liu, A. and Niswander LA. (2011) Grainyhead-like 2 regulates neural tube closure by controlling adhesion molecules during neural fold fusion. Developmental Biology, 353 (1): 38-49. doi: 10.1016/j.ydbio.2011.02.027

Zeng, H., Jia J. and Liu, A. (2010) Coordinated translocation of mammalian Gli proteins and Suppressor of Fused to the primary cilium. PLoS ONE 5(12): e15900. DOI: 10.1371/journal.pone.0015900

Zeng, H., Hoover, AN.  and Liu, A. (2010) PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals. Developmental Biology, 339: 418-428.

Heydeck, W., Zeng, H. and Liu, A. (2009) PCP effector gene Fuzzy regulates cilia formation and Hh signal transduction in mouse. Developmental Dynamics, 238: 3035-3042.

Ko, HW., Liu, A., and Eggenschwiler, J. (2009) Analysis of Hedgehog signaling in mouse intraflagellar transport mutants. Methods in Cell Biology, 93: 347-369. Edited by Stephen King and Gregory Pazour. DOI: 10.1016/S0091-679X(08)93017-X

Jia, J., Kolterud, Å, Zeng, H., Hoover, AN., Teglund, S., Toftgård, R.  and Liu, A. (2009) Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia. Developmental Biology, 330: 452-460. (a Faculty of 1000 Must Read paper, top-five cited DB paper in May 2011)

Hoover, AN., Wynkoop, A., Zeng, H., Jia, J., Niswander, LA. and Liu, A. (2008) C2cd3 is required for cilia formation and Hedgehog signaling in the mouse. Development, 135: 4049-4058

Liu, A., Niswander, LA. (2005) Bone morphogenetic protein signaling and vertebrate nervous system development. Nature reviews neuroscience, 6: 945-954.

Liu, A., Wang, B., Niswander, LA. (2005) Intraflagellar Transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development. 132: 3103-3111.

Liu, A., Wang, C., and Niswander, LA. (2005) Fibroblast Growth Factors in Development. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0003306]

Huangfu, D., Liu, A., Rakeman, A., Murcia, N Niswander, LA., and Anderson, KV (2003) Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature, 426(6962): 83-87. (a Faculty of 1000 Exceptional paper)

Liu, A., Li, JY., Bromleigh, C., Lao, Z, Niswander, LA, and Joyner, AL. (2003) FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. Development. 130(25): 6175-6185. (a Faculty of 1000 Exceptional paper)
Liu, A. and Joyner AL. (2001) Patterning of the midbrain and cerebellum. Annual Review of Neuroscience, Vol. 24, 869-896.
Liu, A. and Joyner, AL. (2001) EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region. Development, 128:181-191. (a Faculty of 1000 Must Read paper)
Joyner AL., Liu, Aand Millet S. (2000) Otx2, Gbx2 and Fgf8 interact to position and maintain a mid/hindbrain organizer. Current Opinion in Cell Biology, 12: 736-741.
Liu, A., Losos, K. and Joyner, AL. (1999) FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Development, 126: 4827-4838.
Liu, A., Joyner, AL. and Turnbull, DH. (1998) Alteration of limb and brain patterning by ultrasound-guided injection of Shh-expressing cells into mouse embryo. Mechanism of Development, 75: 107-115.
Tong, Y., Liu, A., Shang K. and Liu, L. (1997) Establishment and Characterization of Rabbit ES-like Cell Lines. Acta Scientiarum Naturalium Universitatis Pekinensis 33(4): 500-507.

Liu, A. (1995) Gene Targeting in ES cells. In Transgenic Animals, Principles, Techniques and Applications. Ed Xiaoli Tian, Lanying Chen and Rongliang Hu. S&T Press of Jilin Province. pp32-35.

Shang, K., Hu, X., Li, Z. Wang, X., Liu, A., Meng G and Tong, Y. (1994) Effect of different feeder layers on the establishment and character maintenance of mouse ES cell lines. Acta Scientarium Naturalium Universitatis Pekinensis 30(4): 500-508.

Liu, A. and Shang, K. (1994) Targeted disruption of the hprt gene in murine embryonic stem cells. Hereditas(Beijing) 16 (5): 1-5.

Shang, K. and Liu, A. (1992). ES cell and gene manipulation in mammals. in Advance and Progress in Agricultural Biotechnology. ed. Shirong Jia. Chinese University of Science and Technology Press. pp236-254.

Liu, A. and Shang, K. (1991) Gene targeting and transgenic animals. Progress in Biotechnology, 11(3): 20-29.