Department of Biology
 
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Molecular Mechanisms of Mammalian Development and Human Birth Defects

Three out of 100 babies in the United States are born with a birth defect, which causes huge medical, economical and social burdens for the patients, their families and the society. Our long-term goal is to understand the molecular details of normal development, how it is affected by mutations leading to birth defects and identify methods of intervention to prevent and correct these defects. Our current focus is on the roles of the Hedgehog (Hh) signaling pathways and the primary cilium in mammalian development and diseases.