| About Dr. Parente: | |
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Amy D. Parente, Ph.D. Assistant Professor Department of Biology and Department of Chemistry, Penn State Altoona Ph.D., 1999, University of Rochester Postdoctoral Research 1999-2003, Penn State University |
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Education
| 1999 | Ph.D. Bioorganic Chemistry, University of Rochester, Rochester, New York. "Rolling Circle Transcription: Mimicking Viroid Replication." Advisor: Eric T. Kool (Professor of Chemistry, Stanford University as of August, 1999) |
| 1997 | M.S. Chemistry, University of Rochester, Rochester, New York. Advisor: Eric T. Kool |
| 1995 | B.B. with Honors in Chemistry, summa cum laude; B.S. with Honors in Biology, summa cum laude, State University of New York at Fredonia, New York. Advisors: Holly J. Laxson, Chemistry; Kenneth A. Mantai, Biology. |
Research Experience
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January
2004-Present.
Assistant Professor of Biochemistry, Division of
Mathematics and Natural Sciences, Penn State Altoona,
Altoona, PA. Research focus-structure-function studies
of oligonucleotides science education (implementing
alternative pedagogies).
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June
2004-August 2004.
National Science Foundation Visiting Research Fellow,
Department of Chemistry, The Pennsylvania State University.
Advisor: Philip C. Bevilacqua. "Investigations of RNA
Folding: A Combinational Approach to Thermodynamics." |
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November
1999-December 2003.
American Cancer Society Postdoctoral Research Fellow
(2001-2003), Department of Chemistry,
The Pennsylvania State University. Advisor: Philip C.
Bevilacqua. "Regulation of the Protein Kinase PKR by
Hepatitis Delta Virus." |
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January
1995- July 1999.
Research Assistant, Department of Chemistry, University
of Rochester. Advisor: Eric T. Kool "Rolling Circle
Transcription: Production of Novel Therapeutic and
Self-Replication RNAs." |
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August 1994-
May 1995.
Research Assistant, Department of
Chemistry, SUNY Fredonia. Advisor: Holly J. Lawson.
"Synthesis of Novel Ruthenium Complexes of C60 and C70. |
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May 1994- August 1994.
National Science Foundation Undergraduate Research
Fellow, Departments of Biochemistry and Mechanical
Engineering, Virginia Polytechnic Institute and State
University. Advisor: Dr. Michael J. Furey. "Biochemical
Analysis of Bovine Synovial Fluid and Articular Cartilage: A
Preliminary Study Involving Wear."
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September 1993 - May 1994.
Research Assistant, Department of
Chemistry, SUNY Fredonia. Advisor: Michael S. Mulligan.
"Mechanism of Dioxin and Furan Formation from the
Incineration of Municipal Waste."
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Works in Progress
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Diegelman-Parente, A.
(2009) "The Use of Mastery Learning with
Competency-Based Grading In a Sophomore-Level Organic
Chemistry Curriculum."
Submitted.
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Publications
| Diegelman-Parente, A. (2007) Lecture PowerPoints to accompany Organic Chemistry, 5th edition, by Paula Bruice. (Upper Saddle River NJ: Prentice Hall). DVD publication currently available online at: http://www.pearsonhighered.com/educator/academic/product/0,3110,0131963163,00.html# | |
| Tian, B., Bevilacqua, P.C., Diegelman-Parente, A., Mathews, M.B. (2004) “The double-stranded-RNA-binding motif: Interference and much more.” Nat. Rev. Mol. Cell. Biol., Dec 5 (12):1013-23. | |
| Bevilacqua, P.C., Brown, T.S., Chadalavada, D.M., Parente, A.D., Yajima, R. (2003) “Kinetic Analysis of Ribozyme Cleavage.” In Johnson, K.A. (ed.), Kinetic Analysis of Macromolecules: A Practical Approach. Oxford University Press, Oxford, New York, Chapter 3, pp. 49-74. | |
| Diegelman-Parente, A., Bevilacqua, P.C. (2002) “A Mechanistic Framework for Co-transcriptional Folding of the HDV Genomic Ribozyme in the Presence of Downstream Sequence.” J. Mol. Biol., 324:1-16. | |
| Diegelman, A.M., Kool, E.T. (2001) “Chemical and Enzymatic Methods For Preparing Circular Single-stranded DNAs.” In Glick, G.D. (ed.), Current Protocols in Nucleic Acid Chemistry. John Wiley & Sons, Inc., New York, Chapter 5.2. | |
| Seyhan, A.A., Diegelman, A.M., Kool, E.T., Burke, J.M. (2000) “Rolling Circle Transcription of Ribozymes from Promoterless Single-stranded DNA Nanocircles in Mammalian Cells.” Nucleic Acids Symp. Ser. #41, pp. 138-140. | |
| Diegelman, A.M., Kool, E.T. (1999) “Mimicry of the Hepatitis Delta Virus Replication Cycle Mediated by Synthetic Circular Oligonucleotides.” Chem. Biol., 6:569-76. | |
| Diegelman, A.M., Kool, E. T. (1998) “Generation of Circular RNAs and Trans-cleaving Catalytic RNAs by Rolling Transcription of Circular DNA Oligonucleotides Encoding Hairpin Ribozymes.” Nucleic Acids Res. 26: 3235-3241. | |
| Diegelman, A.M., Daubendiek, S.L., Kool, E.T. (1998) “Generation of RNA Ladders by Rolling Circle Transcription of Small Circular Oligodeoxyribonucleotides.” BioTechniques 25:754-758. | |
Funded Projects and Grants
| “Novel Biological Functions of G-quartets: Using Nearest-Neighbor Parameters to Tune Potassium KDs.” Proposal in preparation for National Science Foundation, budget to be determined. Anticipated submission – July 2009. | |
| June 2008 – August 2008, “Novel Biological Functions of G-quartets: Using Nearest-Neighbor Parameters to Tune Potassium KDs.” Undergraduate Research Award, Penn State Altoona, $500. | |
| June 2008 – August 2008, “Novel Biological Functions of G-quartets: Using Nearest-Neighbor Parameters to Tune Potassium KDs.” Penn State Altoona MNS Summer Research Program Award, $1,500. | |
| January 2008 – May 2008, “Novel Biological Functions of G-quartets: Using Nearest-Neighbor Parameters to Tune Potassium KDs.” Undergraduate Research Award, Penn State Altoona, $1,000. | |
| January 2008 – May 2008, “Novel Biological Functions of G-quartets: Using Nearest-Neighbor Parameters to Tune Potassium KDs.” Research Development Grant, Penn State Altoona, $3,100. | |
| January 2008 – May 2008, “Novel Biological Functions of G-quartets: Using Nearest-Neighbor Parameters to Tune Potassium KDs.” Penn State Altoona, course-buyout for external collaborative grant proposal preparation. | |
| January 2007 – December 2007, “Peer-Led Team Learning in CHEM 38 and 39.” Chancellor’s Development Fund Award, Penn State Altoona, $5,000. | |
| June 2006 – August 2006, “The Use of
Oligonucletide Concatenation to Facilitate Sequencing in DNA
Selection Experiments.” Penn State Altoona MNS Summer
Research Program Award, $1,500. |
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| June 2004-August 2004, “Investigations of RNA Folding: A Combinatorial Approach to Thermodynamics,” National Science Foundation Visiting Research Fellowship, $15,000. | |
| January 2001 – December 2003, “Regulation of the Protein Kinase PKR by Hepatitis Delta Virus RNA,” American Cancer Society Postdoctoral Research Fellowship, $118,000. | |
| June 1999, “Studies towards the Evolution of a Self-Replicating RNA,” Gordon Research Conference Student Travel Award, $500. | |
| March 1999, “Rolling Circle Synthesis of Hepatitis Delta Ribozymes as Novel Therapeutic Agents,” American Chemical Society Women Chemists Committee Travel Award, $500. | |
Presentations
| Parente, A. D. “CHEM 210 - Combining Peer-Led Team Learning (PLTL) with Competency-Based Grading at Penn State Altoona” All-Campus Chemistry Meeting, The Pennsylvania State University, University Park PA, May 2008 | |
| Andrew T. Catherine, Stephanie N. Shishido and Parente, A. D. “Using Circular Dichroism and Nearest-Neighbor Parameters to Tune Potassium KDs of DNA G-Quartets” 6th Annual Undergraduate Research Fair, Penn State Altoona, April 2008 *poster took first place | |
| Parente, A. D. “Research is Critical” ACS CAN Leadership Summit and Lobby Day, American Cancer Society, Washington D.C., September 2007 | |
| Parente, A. D. “CHEM 38 – Combining Peer-Led Team Learning (PLTL) with Competency-Based Assessment at Penn State Altoona.” Workshops on Peer-Led Team Learning, The City College of New York, New York NY, July 2007 | |
| Parente, A. D. “CHEM 38 – Combining Peer-Led Team Learning (PLTL) with Competency-Based Assessment at Penn State Altoona.” The Kumler Conference, Fredonia State University, Fredonia NY, May 2007 | |
| Parente, A. D. “CHEM 38 – Combining Peer-Led Team Learning (PLTL) with Competency-Based Assessment at Penn State Altoona.” All-Campus Chemistry Meeting, The Pennsylvania State University, University Park PA, May 2007 | |
| Parente, A. D. “Research is Critical.” Breast Cancer Awareness Program, Penn Cambria High School, Cresson PA, May 2007. | |
| Parente, A. D. “Research is Critical.” Breathe-Free at the Capitol, American Cancer Society, Harrisburg PA, May 2007. | |
| Parente, A. D. “ACS Research – a personal story.” ACS Research Promotion Workshop, The Penn Stater, State College PA, October 2006. | |
| Parente, A. D. “Celebration on the Hill – a personal remembrance.” Central Region Regional Volunteer Forum, American Cancer Society, Altoona PA, October 2006. | |
| Parente, A. D. “Research is Critical.” 2nd Annual Celebration on the Hill, American Cancer Society, Washington D.C., September 2006. | |
| Parente, A. D. “Research is Critical.” Evening of Advocacy, American Cancer Society, Johnstown PA, August 2006. | |
| Parente, A. D. “Making Strides.” Making Strides Against Breast Cancer Kickoff, American Cancer Society, Altoona PA, May 2006. | |
| Parente, A. D. “Making Strides Against Breast Cancer.” Keynote speaker at American Cancer Society’s Making Strides Against Breast Cancer event, October 2, 2005, Community Arts Center, Johnstown, Pennsylvania. | |
| Parente, A. D. “What to Expect from a Chemistry Graduate Program.” Panel discussion participant, August 12, 2005, Department of Chemistry, Penn State University, University Park, Pennsylvania. | |
| Parente, A. D. “What a Difference a Year Can Make.” Guest speaker at Pennsylvania Division American Cancer Society Summit Meeting, October 10, 2003, Nittany Lion Inn, Penn State University, University Park, Pennsylvania. | |
| Parente, A. D. “What a Difference a Year Can Make.” Guest speaker at American Cancer Society Seventh Annual Coaches vs. Cancer Celebrity Golf Tournament, May 30, 2003, The Penn Stater Conference Center, State College, Pennsylvania. | |
| Parente, A. D. “The Cancer Research of Today is the Cure for Tomorrow.” Guest speaker at American Cancer Society Second Annual Mount Union Relay for Life Kick-Off, September 23, 2002, Christian Missionary Alliance Church, Mt. Union, Pennsylvania. | |
| Parente, A. D. “DNA: Unlocking the Secrets of Your World.” Guest lecturer for 2002 Workshops for Science Educators, July 9, 2002, Penn State University, University Park, Pennsylvania. | |
| Parente, A. D. “The Cancer Research of Today is the Cure for Tomorrow.” Guest speaker at American Cancer Society Sixth Annual Coaches vs. Cancer Celebrity Golf Tournament, May 17, 2002, Nittany Lion Inn, Penn State University, University Park, Pennsylvania. | |
| Parente, A. D. “Biosensors.” Mini-workshop for Science Educators, May 10, 2002, State College Area High School, State College, Pennsylvania. | |
| Diegelman, A.M. et al. “Research at the Interface of Biology and Chemistry.” Presentation for Take Our Daughter’s To Work Day, April 26, 2001, Penn State University, University Park, Pennsylvania. | |
| Diegelman, A.M. et al. “Earth Day.” Interactive workshop for elementary school students, April 11, 2001, Park Forest Elementary School, State College, Pennsylvania. | |
| Diegelman, A.M. et al. “Wastewater Treatment: Science and Society.” Interactive workshop for high school students, March 23, 2001, State College Area High School, State College, Pennsylvania. | |
| Diegelman, A.M. "The Cancer Research of Today is the Cure for Tomorrow.” Guest speaker at American Cancer Society Fifth Annual Clinton County Relay for Life, May 19, 2001, Lock Haven University, Lock Haven, Pennsylvania. | |
| Diegelman, A.M. and Bevilacqua, P.C. “A Mechanistic Framework for Co-transcriptional Cleavage of the Genomic Hepatitis Delta Ribozyme.” Poster presentation at the Sixth Johns Hopkins Folding Meeting, March 17-20th, 2001, Coolfont Conference Center, Berkeley Springs, West Virginia. | |
| Diegelman, A.M. “What is the Workshop Model? Experiencing a Student-led Workshop.” Presentation at the Conference on Active Learning in Science Courses, April 28-30, 2000, University of Miami, Coral Gables, Florida. | |
| Diegelman, A.M. “Workshop on Workshops.” Presentation at 1st Rocky Mountain Conference on Peer-Led Team Learning, August 7-11, 1999, University of Montana, Missoula, Montana. | |
| Diegelman, A.M. and Kool, E.T. “Studies Towards the Evolution of a Self-replicating RNA.” Poster presentation at the Gordon Research Conference on Bioorganic Chemistry, June 13-18th, 1999, Proctor Academy, Andover, New Hampshire. | |
| Diegelman, A.M. and Kool, E.T. “Rolling Circle Synthesis of Hepatitis Delta Ribozymes as Novel Therapeutic Agents.” Presentation at the 217th American Chemical National Meeting, March 21-25th, 1999, Anaheim, California. | |
| Diegelman, A.M., Varma-Nelson, P., Kampmeier, J.A. and Cracolice, M.S. “Workshop Chemistry: Peer-Led Team Learning.” Presentation at 15th Biennial Conference on Chemical Education, August 9-13th, 1998, University of Waterloo, Waterloo, Ontario, Canada. | |
| Diegelman, A.M. and Kool, E.T. “Rolling Circle Transcription: Production of Hairpin Ribozymes.” Poster presentation at the Buffalo Medicinal Chemistry Symposium, May 19th, 1997, University at Buffalo, Buffalo, New York. | |
| Diegelman, A.M. and Furey, M.J. “Biochemical Analysis of Bovine Synovial Fluid and Articular Cartilage: A Preliminary Study Involving Wear.” Presentation at the NSF Summer Research Program, August 1994, Virginia Polytechnic Institute, Blacksburg, Virginia. | |
Supervision of Undergraduates
| Heather McKinney. “Implementation and Assessment of Mastery Learning with Competency-Based Grading in the Organic Chemistry Curriculum.” Fall 2008 – present. | |
| Andrew Catherine and Selena Frank. “Novel Biological Functions of G-quartets: Using Nearest-Neighbor Parameters to Tune Potassium KDs.” Fall 2008 – present. | |
| Stephanie Shishido and Andrew Catherine. “Novel Biological Functions of G-quartets: Using Nearest-Neighbor Parameters to Tune Potassium KDs.” Fall 2007 – Summer 2008. | |
| Stephanie Shishido. “Novel Biological Functions of G-quartets: Using Nearest-Neighbor Parameters to Tune Potassium KDs.” Summer 2007. | |
| Mosquea, Leocadia and Jennifer Fraundorfer. “The Use of Oligonucletide Concatenation to Facilitate Sequencing in DNA Selection Experiments.” Summer 2006. | |
| Mosquea, Leocadia, Jennifer Fraundorfer, and Amanda McClelland. “The Use of Oligonucletide Concatenation to Facilitate Sequencing in DNA Selection Experiments.” Spring 2005. | |
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Other Evidence of Research Expertise
| Manuscript Referee | |
| Journal of Molecular Biology | |
| RNA | |
| Grant Proposal Reviewer | |
| Center for Research, College of Science and Health, William Patterson University | |
| American Cancer Society's Community Partnership Grant Program | |
Award/Honors/Recognition
| § | Featured Faculty Member – Penn State Altoona website - http://www.aa.psu.edu/now/video.asp (October 22, 2007) | |
| § | “Professor Parente Probes for Cancer Cure.” Altoona Mirror feature article page A1, A5 (July 9, 2007) | |
| § | “Quest for a Cure” Ivyleaf page 9 (2006) - http://www.altoona.psu.edu/ivyleaf/fa06/collegenews14.htm | |
| § | American Cancer Society Mission Award for Research, 2006 | |
| § | Featured researcher in the American Cancer Society’s 2001-2002 Annual Report | |
| § | Featured researcher in the American Cancer Society’s “Strides Against Breast Cancer 2002 Calendar” | |
| § | American Cancer Society Postdoctoral Research Fellowship, 2001-2003 | |
| § | Gordon Research Conference Student Travel Award, 1999 | |
| § | American Chemical Society’s Women Chemists Committee Travel Award, 1999 | |
| § | Weissberger Memorial Fellowship, Department of Chemistry, University of Rochester, 1998 | |
| § | Carl A. Whiteman Teaching Award, Department of Chemistry, University of Rochester, 1997 | |
| § | Sherman Clarke Fellowship, Department of Chemistry, University of Rochester, 1995-1999 | |
| § | Senior Chemistry Award, Department of Chemistry, SUNY Fredonia, 1995 | |
| § | Phi Beta Kappa Achievement Award, SUNY Fredonia, 1995 | |
| § | Dingledy Scholar Award (outstanding junior), Department of Chemistry, SUNY Fredonia, 1994 | |
| § | Eastern Analytical Symposium Student Award Winner, Eastern Analytical Symposium, 1994 |
| § | Fredonia Scholar Award, Faculty Student Association, SUNY Fredonia, 1992 | |
| § | Freshman Chemistry Award, Department of Chemistry, SUNY Fredonia, 1992 | |
| § | Edward D. Steele Scholarship, Fredonia College Foundation, SUNY Fredonia, 1991 | |
| § | Sigma Tau Pi, Chemistry Honor Society, SUNY Fredonia | |
Professional Affiliations/Associations
| § | Natural Sciences Advisory Council, SUNY Fredonia, 2007 - present | |
| § | American Cancer Society Advisory Board Member (Pennsylvania Division), 2008 - present | |
| § | American Cancer Society Advisory Board Member (PA Central Division, Blair Unit), 2007 - present | |
| § | American Cancer Society Legislative Ambassador, 2006 – present (Advocacy Chair, 2007 – present) | |
| § | The RNA Society, 2006-present | |
| § | American Association for the Advancement of Science, 2000-present | |
| § | American Chemical Society, 1993-present | |
| § | American Institute of Chemists, 1995-1996 |
Teaching Experience
| January 2004 – Present. Assistant Professor of Biochemistry, Division of Mathematics and National Sciences, Penn State Altoona, Altoona, PA. Courses taught – CHEM 210 & 212 – Organic Chemistry I and II (previously CHEM 38 & 39), B M B 401 & 402 – General Biochemistry I and II, BIOL 416 – Biology of Cancer, CHEM 001 (previously CHEM 2) – Molecular Science, and CHEM 110 (previously CHEM 14) General Chemistry Laboratory. | |
| August 2002 - December 2003. Lecturer, Division of Mathematics and National Sciences, Penn State Altoona, Altoona, PA. Instructor for B M B 401 and 402 – General Biochemistry I and II. | |
| August 1995 - May 1997. Teaching Assistant, Department of Chemistry, University of Rochester. General Chemistry laboratory assistant and recitation teaching assistant; Organic Chemistry workshop leader and Honors Organic Chemistry laboratory assistant. | |
| August 1992 - May 1995. Laboratory Assistant and Recitation Teaching Assistant, Departments of Biology and Chemistry, SUNY Fredonia. Laboratory and Recitation Teaching Assistant for General and Honors General Chemistry, Organic Chemistry, and Zoology. | |
| August 1992 - May 1995. Head Chemistry and Biology tutor, Learning Center, SUNY Fredonia. Head tutor and interface with faculty of both departments. | |